MODE OF ACTION OF ISONIAZID

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Abstract
Against Mycobacterium tuberculosis H37Rv, isoniazid was initially bacteriostatic rather than bactericidal, and massive quantities of the drug were no more effective than smaller quantities. Isoniazid may interfere with the formation of an essential metabolite. Tubercle bacilli susceptible to isoniazid became radioactive when grown in a medium containing isoniazid labeled with a C14 in the carboxyl position. Resistant bacilli did not become radioactive when grown in media containing C14-labeled isoniazid.