Cell-cycle checkpoints and cancer
Top Cited Papers
- 17 November 2004
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 432 (7015) , 316-323
- https://doi.org/10.1038/nature03097
Abstract
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.Keywords
This publication has 94 references indexed in Scilit:
- 53BP1, an activator of ATM in response to DNA damageDNA Repair, 2004
- Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayGenes & Development, 2004
- Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiationOncogene, 2004
- The Mre11 complex is required for ATM activation and the G2/M checkpointThe EMBO Journal, 2003
- Requirement of the MRN complex for ATM activation by DNA damageThe EMBO Journal, 2003
- DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationNature, 2003
- Cell cycle checkpoint signaling through the ATM and ATR kinasesGenes & Development, 2001
- ATM: Genome stability, neuronal development, and cancer cross pathsPublished by Elsevier ,2001
- Topoisomerase Poisons: Harnessing the Dark Side of Enzyme MechanismJournal of Biological Chemistry, 1995
- Checkpoints: Controls That Ensure the Order of Cell Cycle EventsScience, 1989