Chemical Characterization of Ectopic ACTH Purified From a Malignant Thymic Carcinoid Tumor
- 1 October 1976
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 43 (4) , 831-835
- https://doi.org/10.1210/jcem-43-4-831
Abstract
ACTH was purified from a thymic tumor associated with ectopic ACTH production by gel filtration and ion exchange chromatography. Amino acid composition and C- and N-terminal analyses indicated that this tumor ACTH was comprised of the 2–38 sequence of authentic pituitary ACTH. Theobservations suggest that the mode of cleavage of this tumor ACTH from its precursor is different from that of pituitary ACTH.Keywords
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