Delayed hypersensitivity to extracts from primary sarcomata in the autochthonous host

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Abstract
All rats with benzpyrene‐induced primary tumours responded by producing varying degrees of delayed hypersensitivity reactions to their own tumour extracts after the complete removal of the tumour. After partial removal of the tumour the delayed hypersensitivity reactions were uniformly shown to be negative. Gradual increase in delayed hypersensitivity response as shown by the gradual increase in foot‐pad swelling was detected after each successive tumour transplant and excision in the same animal. The delayed hypersensitivity phenomena are not specific to each individual tumour and there appears to be almost complete cross‐reactivity. The possible reasons for these observations are discussed.