A Comparison of Mutation Induced by Acute X and Chronic Gamma Irradiation in Mice

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Abstract
An experiment is described in which male mice received, in one group, an X-ray dose of 600 r given at a high dose-rate and, in a second group, a dose of 600 r of cobalt 60 gamma rays given at a low dose-rate; spermatogonial specific locus mutation rates were studied. The induced mutation rate was significantly lower in the chronically irradiated group; this confirms the report of Russell, Russell and Kelly (1958). A significant difference in the mutability of the d-locus was found between experiments carried out at Harwell and the acute X-ray experiments reported by Russell and Russell (1959).