RESPONSES OF ELDERLY SUBJECTS TO MONO-VALENT A-USSR-77 (H1N1) AND TRIVALENT A-USSR-77 (H1N1)-A-TEXAS-77 (H3N2)-B-HONG KONG-72 VACCINES

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Abstract
Antibody responses to vaccination with monovalent influenza A/USSR/77 (H1N1) and trivalent influenza A/USSR/77 (H1N1)-A/Texas/77 (H3N2)-B/Hong Kong/72 vaccines were examined in a group of elderly persons, most of whom had received > 1 influenza vaccination in the previous 5 yr. About 72% had a 4-fold or greater increase in hemagglutination inhibition (HAI) titer to A/USSR and 92% had postvaccine titers .gtoreq. 1:40. There were no differences in antibody responses to A/USSR between recipients of monovalent and trivalent vaccines. No booster effect of a 2nd injection of A/USSR was observed in subjects who had failed to respond to the 1st injection. Although there was a significant correlation between postvaccine HAI titers to A/USSR and to A/Texas, the responses to A/Texas and B/Hong Kong were modest or minimal compared with those to A/USSR. This serologic data may be relevant to the results of surveillance studies that suggest a limited advantage of repeated vaccinations with H3N2 subtypes and should help in evaluating the results of this practice.