Antithrombin III Phenylalanines 122 and 121 Contribute to Its High Affinity for Heparin and Its Conformational Activation
Open Access
- 1 May 2003
- journal article
- Published by Elsevier
- Vol. 278 (18) , 15941-15950
- https://doi.org/10.1074/jbc.m212319200
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Elimination of P1 Arginine 393 Interaction with Underlying Glutamic Acid 255 Partially Activates Antithrombin III for Thrombin Inhibition but Not Factor Xa InhibitionPublished by Elsevier ,2002
- Identification of Critical Molecular Interactions Mediating Heparin Activation of Antithrombin Implications for the Design of Improved Heparin AnticoagulantsTrends in Cardiovascular Medicine, 2002
- The Role of Arg46 and Arg47 of Antithrombin in Heparin BindingBiochemistry, 1999
- The Oligosaccharide Side Chain on Asn-135 of α-Antithrombin, Absent in β-Antithrombin, Decreases the Heparin Affinity of the Inhibitor by Affecting the Heparin-Induced Conformational ChangeBiochemistry, 1997
- Lysine Residue 114 in Human Antithrombin III Is Required for Heparin Pentasaccharide-mediated ActivationPublished by Elsevier ,1997
- The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site 1 1Edited by R. HuberJournal of Molecular Biology, 1997
- Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin IIIPublished by Elsevier ,1996
- Mechanism of Heparin Activation of Antithrombin. Evidence for Reactive Center Loop Preinsertion with Expulsion upon Heparin BindingBiochemistry, 1996
- Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the .beta.-antithrombin III isoform with enhanced heparin affinityBiochemistry, 1995
- Antithrombins Southport (Leu 99 to Val) and Vienna (Cln 118 to Pro): two novel antithrombin variants with abnormal heparin bindingBritish Journal of Haematology, 1995