Protective effect of 3‐hydroxy‐3‐methylglutaric acid in alcohol‐induced lipemia
- 1 July 1976
- Vol. 11 (7) , 526-529
- https://doi.org/10.1007/bf02532897
Abstract
Oral administration of 1 g of 3‐hydroxy‐3‐methylglutaric acid (HMG) before the ingestion of whiskey and a fatty meal markedly reduced the elevation of serum triglycerides, β‐lipoproteins, phospholipids, and cholesterol in man. In rats receiving an ethanol and corn oil mixture, HMG also inhibited the increase in postprandial serum and liver lipids. A comparative study of HMG and nicotinic acid in rats showed that, therapeutically, 50 mg MHG/kg body weight is equivalent to 200 mg nicotinic acid/kg body weight in offering almost total protection against lipemic effects of ethanol.This publication has 24 references indexed in Scilit:
- Studies on the hypolipidemic and hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acid in rabbitsAtherosclerosis, 1974
- 3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis, 1973
- Alcohol-Induced Hyperlipidemia and Beta LipoproteinsScience, 1973
- EFFECTIVENESS OF 3-HYDROXY-3-METHYLGLUTARIC ACID IN FAMILIAL HYPERCHOLESTEROLÆMIAThe Lancet, 1973
- In vitro and in vivo inhibition of hepatic cholesterol synthesis by 3-hydroxy-3-methylglutaric acidBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- Nicotinic acid and alcohol-induced lipemiaAtherosclerosis, 1971
- Effect of 3-hydroxy-3-methylglutaric acid on blood lipids in normal and cholesterol-fed ratsCellular and Molecular Life Sciences, 1968
- Enhancement of Alimentary Lipemia by Preprandial AlcoholThe Lancet Healthy Longevity, 1968
- Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidCellular and Molecular Life Sciences, 1967
- Abnormal lipid tolerance and hyperlipemia in acute ethanol-treated ratsLife Sciences, 1963