A NEW BIOLOGICAL METHOD FOR THE ASSAY OF DEPOLARIZING SUBSTANCES USING THE ISOLATED SEMISPINALIS MUSCLE OF THE CHICK
Open Access
- 1 September 1960
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 15 (3) , 412-416
- https://doi.org/10.1111/j.1476-5381.1960.tb01265.x
Abstract
The isolated semispinalis cervicis muscle of a 3 to 10 days old chick has been found to provide a very useful assay method for depolarizing substances. There are three main advantages of this preparation over that of the rectus abdominis of the frog: (a) quick relaxation without any artificial stretching of the muscle, (b) greater sensitivity to depolarizing drugs, and (c) no falling off in sensitivity for at least 2 hr.Keywords
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