ACTIVITIES OF CARDIAC AND HEPATIC PYRUVATE-DEHYDROGENASE COMPLEX ARE DECREASED AFTER SURGICAL STRESS

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  • 1 February 1986
    • journal article
    • research article
    • Vol. 12  (2) , 189-197
Abstract
The work investigated the effects of surgical stress on the activities of cardiac and hepatic pyruvate dehydrogenase complex (active form, PDHa) in fed rats. PDHa activities in heart and liver were decreased within 4h of surgery with maximum inhibition at 24 h after surgery. PDHa activities remained low until the fourth (liver) and eighth (heart) post-operative days. The decreased activities found at 4 h and 24 h after surgery were associated with increased plasma fatty acid concentrations, and inhibition of lipolysis resulted in reactivation of the enzyme complex. The results are discussed with reference to the control of pyruvate dehydrogenase activities by the oxidation of fat fuels and multisite phosphorylation in stress states, and its possible importance in glucose conservation after surgery and trauma.

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