Presenilin 1: more than just γ-secretase
- 1 August 2005
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 33 (4) , 559-562
- https://doi.org/10.1042/bst0330559
Abstract
Presenilin 1 plays a central catalytic role in the γ-secretase processing of amyloid precursor protein, Notch and many other substrates. However, this core component clearly mediates independently several other physiological roles in the cell/neuron. Besides its involvement in β-catenin degradation, we discuss here the recent implication of presenilin 1 in the turnover of the intercellular cell adhesion molecule, telencephalin, through a degradation route that bears autophagic characteristics. Activation of the endosomal/lysosomal system in general and autophagic degradation in particular, is finally briefly discussed in the context of neurodegenerative diseases.Keywords
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