The Relative Effect of Methionine Sulfoximine on Different Animal Species

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Abstract
The minimum toxic dosages of methionine sulfoximine for dogs, rats, and monkeys have been established and it has been found that rats and monkeys are approximately 100 times more resistant to this drug than dogs. The development of methionine sulfoximine-induced seizures in monkeys and dogs has been suppressed by the administration of methionine. The approximate ratio for the amount of methionine which will prevent seizures to the amount of methionine sulfoximine which will cause them has been determined for dogs and monkeys. This ratio has been found to be considerably higher for the dog than for the monkey. The relationship of these data to results already published dealing with the possible deleterious effect of commercially agenized flour on humans has been discussed.