GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE
- 1 August 1976
- journal article
- research article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 3 (4) , 275-286
- https://doi.org/10.1111/j.1744-313x.1976.tb00584.x
Abstract
SUMMARY: Recombinant‐inbred strains of mice, as well as the progenitor strains from which they were derived, were evaluated with respect to the capacity of B cells to respond to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS‐III) and the amount of suppressor and amplifier T cell activity present. None of these functional activities was found to be linked to genes within the major histocompatibility (H‐2) or the IgCH allotype complex, and several autosomal genes appeared to govern the expression of each of these characteristics.Keywords
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