Defect of urinary concentration capacity in cephaloridine-administered rats.

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Abstract
The nephrotoxic effects of cephaloridine on the renal concentration capacity were examined in rats that had received a single intravenous injectoin of cephaloridine (100 or 500 mg/kg body weight). An increase in urinary volume and a decrease in urinary osmotic pressure were observed continuously from the first to the sixth day in the 500 mg/kg group, but not in the 100 mg/kg group. In addition, rises in plasma levels of arginine-vasopressin were observed in the 100 and 500 mg/kg groups. Furthermore, responsiveness to exogenous arginine-vasopressin was investigated in the cephaloridine-administered rats under ethanol anesthesia. The injection of arginine-vasopressin caused relatively slight responses, in terms of the urine flow and urinary osmolality, in the cephaloride-administered group in comparison to the control group. These findings indicate that cephaloridine induces a vasopressin-resistant polyuria, and strongly suggests that cephaloridine does damage the collecting tubules in the kidney.

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