CHANGES IN CGMP AND CAMP CONTENT IN ESTROGEN-STIMULATED RAT UTERUS - TEMPORAL RELATIONSHIP WITH OTHER PARAMETERS OF HORMONAL-STIMULATION

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 4  (2) , 145-158
Abstract
The effect of estradiol-17.beta., estriol, diethylstilbestrol and nafoxidine on rat uterine c[cyclic]GMP content was studied in relation with their respective estrogenic potency. Confirming previous results from Kuehl et al., a rise in uterine cGMP and a simultaneous decrease in cAMP content in treated animals were observed. The reverse effect was obtained in the vagina after stimulation with estradiol or estriol. In the uterus, all compounds tested induced 2 main waves of cGMP increase corresponding to the 2 main phases of the estrogenic response i.e., the early fluid imhibition and the later period of true growth. No direct relationship could be established between the late rise in cGMP and true growth responses. A causal link between the 1st accumulation of uterine cGMP and the wet weight response in the early phase of estrogenic action was suggested by the comparison of time-course effects of the different compounds used on those 2 parameters.