Pulmonary Edema and Hemorrhage Induced by Hypothalamic Lesions in Rats

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Abstract
Hypothalamic lesions were produced in anesthetized rats by a stereotaxic instrument. Acute pulmonary edema developed in 18 rats less than 24 hrs. after placement of these lesions. Severe hemorrhage and edema was found, with alveoli distended by fibrous transudate and often erythrocytes. Calculations reveal that only the accumulation of a dilute transudate such as plasma could account for the increased percentage of lung fluid. In another group of animals which showed pulmonary pathology when sacrificed 24 hrs. post-operatively, there was a spotty distr. of hemorrhagic lesions. Hyperthermia was not essential to the development of pulmonary edema and hemorrhage following hypothalamic lesions. Identification of the destroyed region revealed that there was bilateral damage just overlying the anterior half of the optic chiasm in most of these edematous animals.

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