PARTICIPATION OF BLOOD BORN CELLS IN RAT MASUGI NEPHRITIS

Abstract
Participation of blood born cells in rat Masugi nephritis was investigated with ultrastructural demonstration of peroxidase, in addition to conventional light microscopy and EM. Polymorphonuclear leukocytes appear immediately and transiently after injection of nephrotoxic serum. Hypercellularity in the early stage of the disease consists mainly of monocytes and macrophages. Proteinuria and monocyte infiltration persists for up to 124 days; focal sclerosis with hyaline material appears in later stages.