Lysosomes are associated with microtubules and not with intermediate filaments in cultured fibroblasts.

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Abstract
Double immunofluorescent labeling experiments for lysosomes and either microtubules or vimentin intermediate filaments in cultured well-spread fibroblasts [NRK] show a remarkable degree of superposition of the lysosomes and the microtubules. Under 2 different sets of conditions where the microtubules and intermediate filaments are well segregated from one another, the lysosomes remain codistributed with the microtubules. This specific association of lysosomes with microtubules possibly reflects some type(s) of linkage(s) between them, and such linkages may play an important role in the location and intracellular transport of lysosomes inside cells.