Longitudinal study of the effect of calcium pidolate on bone mass in eugonadal women

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Abstract
Seventy-two eugonadal women, mean age 39±4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80±0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distributed into two groups: 36 women undergoing treatment with 1 g/day of elemental calcium in the form of calcium pidolate and 36 women not treated. One year later, total body BMC, regional BMC in arms, legs and trunk, 24-hour urinary calicum excretion (Ca 24 hour), fasting urinary calcium/creatinine ratio, and serum tartrate-resistant acid phosphatase concentration were measured in both groups. There was a significant increase in total body and regional BMC (PPPP2=0.925, P<0.001). The untreated group showed no changes. These results indicate that administration of 1 g/day of elemental calcium in the form of calcium pidolate to eugonadal women increases total and regional bone mass.