PROGESTERONE AND 4-PREGNEN-20±-OL-3-ONE IN THE TISSUES OF PREGNANT RATS1

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Abstract
Concentrations of two progestational hormones, progesterone and 4-pregnen-20[alpha]-ol-3-one, were estimated in tissues of pregnant rats in the last third of pregnancy. Measurable quantities of both compounds were obtained from ovaries (progesterone, 7.9 [mu]g. per gm.; 4-pregnen-20[alpha]-ol-3-one, 10.1 [mu]g. per gm.), blood (progesterone, 0.07 [mu]g. per gm.; 4-pregnen-20[alpha]-ol-3-one, 0.03 [mu]g. per gm.), and fat (progesterone, 0.12 [mu]g- per gm.; 4-pregnen-20[alpha]-ol-3-one, 0.08 [mu]g. per gm.). Fetuses, placentae, amniotic fluid and uteri on analyses gave negative findings. The conclusion was reached that ovaries are the major source of progestational hormones in the rat during late pregnancy.