Thermodynamics of ubiquitin unfolding
- 1 March 1994
- journal article
- research article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 18 (3) , 246-253
- https://doi.org/10.1002/prot.340180305
Abstract
The energetics of ubiquitin unfolding have been studied using differential scanning microcalorimetry. For the first time it has been shown directly that the enthalpy of protein unfolding is a nonlinear function of temperature. Thermodynamic parameters of ubiquitin unfolding were correlated with the structure of the protein. The enthalpy of hydrogen bonding in ubiquitin was calculated and compared to that obtained for other proteins. It appears that the energy of hydrogen bonding correlates with the average length of the hydrogen bond in a given protein structure. © 1994 John Wiley & Sons, Inc.Keywords
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