Recovery of Consciousness after Thiopental or Propofol
- 1 March 1997
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 86 (3) , 613-619
- https://doi.org/10.1097/00000542-199703000-00013
Abstract
Background: Currently, there exists no effective monitor that can predict the probability of a patient being conscious during general anesthesia. The electroencephalogram-derived bispectral index (BIS) is a promising new method to assess anesthetic adequacy. This study used the BIS to predict the probability of recovery of consciousness after a single bolus induction dose of propofol or thiopental. Methods: Twenty unpremedicated surgical patients were anesthetized with 4 mg/kg thiopental and 20 patients with 2 mg/kg propofol. The BIS was monitored throughout the study. After induction, before administration of neuromuscular blocking agent, a tourniquet was applied to one arm and inflated above the systolic blood pressure. This allowed preservation of the ability to move the hand after neuromuscular blocking agent onset. Patients were then prompted to squeeze the investigator's hand every 30 s, until they responded to the request. At the time of response, anesthesia was reinduced and the study terminated. Results: The BIS at loss of consciousness and recovery of a response was not statistically different between propofol and thiopental. No patient with a BIS less than 58 was conscious. In both groups, a BIS of less than 65 signified a less than 5% probability of return of consciousness within 50 s. Conclusion: The BIS can be used to predict probability of recovery of consciousness after a single injection of either thiopental or propofol.Keywords
This publication has 19 references indexed in Scilit:
- Eeg bispectrum predicts movement during thiopental/isoflurane anesthesiaJournal of Clinical Monitoring and Computing, 1995
- An introduction to bispectral analysis for the electroencephalogramJournal of Clinical Monitoring and Computing, 1994
- The Electroencephalogram Does Not Predict Depth of Isoflurane AnesthesiaAnesthesiology, 1994
- Bispectral analysis of the electroencephalogram during induction of anesthesia may predict hemodynamic responses to laryngoscopy and intubationElectroencephalography and Clinical Neurophysiology, 1994
- No Correlation between Quantitative Electroencephalographic Measurements and Movement Response to Noxious Stimuli during Isoflurane Anesthesia in RatsAnesthesiology, 1992
- Does Opioid “Anesthesia” Exist?Anesthesiology, 1990
- Changes in EEG Spectral Edge Frequency Correlate with the Hemodynamic Response to Laryngoscopy and IntubationAnesthesiology, 1987
- Power Spectrum Correlates of Changes in Consciousness during Anesthetic Induction with EnfluraneAnesthesiology, 1986
- Surgically Induced Hypertension in Brain Dead PatientsAnesthesia & Analgesia, 1985
- Intraoperative Awareness during High-dose Fentanyl-Oxygen AnesthesiaAnesthesiology, 1981