CYCLOTRON-PRODUCED ZN-62 - ITS POSSIBLE USE IN PROSTATE AND PANCREAS SCANNING AS A ZN-62 AMINO-ACID CHELATE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (8) , 815-821
Abstract
62Zn is a positron emitter that localizes in pancreas, prostate and liver. Cyclotron-produced 62Zn was separated by column chromatography and evaluated in vivo as the chelate of 5 amino acids and also as 62ZnCl2. Tissue-distribution studies were done in normal animals from 0.7-23 h after i.v. administration. Pancreas-to-liver ratios (per g) of about 1.0 were found at 1.5 h in studies on rats, dogs and monkeys. Pancreas was as difficult to separate from liver in 62Zn (amino acid) images as in 75Se-selenomethionine images. Some studies were done with 65Zn to determine the effects of carrier Zn and molar ratios of ligand. The highest ratio of pancreas to liver in these studies was 1.44. This uptake ratio decreased with increasing amounts of histidine, but the ratio is increased by adding carrier Zn because there resulted a decrease in liver uptake and no change in the pancreas uptake. There was sufficient specificity of pancreas and prostate uptake to make feasible emission computed tomography with 62Zn.

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