Splenic marginal zone B cells in humans: Where do they mutate their Ig receptor?
Open Access
- 6 October 2005
- journal article
- review article
- Published by Wiley in European Journal of Immunology
- Vol. 35 (10) , 2789-2792
- https://doi.org/10.1002/eji.200535446
Abstract
Human IgM+IgD+CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. Küppers has studied the expression of the enzyme activation‐induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID‐expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed. See accompanying article: http://dx.doi.org/10.1002/eji.200535134Keywords
This publication has 21 references indexed in Scilit:
- Human splenic marginal zone B cells lack expression of activation‐induced cytidine deaminaseEuropean Journal of Immunology, 2005
- Intestinal bacteria and development of the B-lymphocyte repertoireTrends in Immunology, 2005
- Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infectionsNature, 2005
- Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoireBlood, 2004
- A bird's eye view on human B cellsSeminars in Immunology, 2004
- Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage DevelopmentImmunity, 2003
- Marginal-zone B cellsNature Reviews Immunology, 2002
- Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)Cell, 2000
- Human marginal-zone B cellsImmunology Today, 1998
- Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent processCell, 1995