Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
Open Access
- 1 April 1999
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 2 (4) , 358-363
- https://doi.org/10.1038/7268
Abstract
We measured endogenous cannabinoid release in dorsal striatum of freely moving rats by microdialysis and gas chromatography/mass spectrometry. Neural activity stimulated the release of anandamide, but not of other endogenous cannabinoids such as 2-arachidonylglycerol. Moreover, anandamide release was increased eightfold over baseline after local administration of the D 2-like (D2, D3, D4) dopamine receptor agonist quinpirole, a response that was prevented by the D2-like receptor antagonist raclopride. Administration of the D1-like (D 1, D5) receptor agonist SKF38393 had no such effect. These results suggest that functional interactions between endocannabinoid and dopaminergic systems may contribute to striatal signaling. In agreement with this hypothesis, pretreatment with the cannabinoid antagonist SR141716A enhanced the stimulation of motor behavior elicited by systemic administration of quinpirole. The endocannabinoid system therefore may act as an inhibitory feedback mechanism countering dopamine-induced facilitation of motor activity.Keywords
This publication has 43 references indexed in Scilit:
- SR141716A, a potent and selective antagonist of the brain cannabinoid receptorPublished by Wiley ,2001
- Molecular Aspects of Cannabinoid ReceptorsCritical Reviews™ in Neurobiology, 1997
- Transacylase‐Mediated and Phosphodiesterase‐Mediated Synthesis of N‐Arachidonoylethanolamine, an Endogenous Cannabinoid‐Receptor Ligand, in Rat Brain MicrosomesEuropean Journal of Biochemistry, 1996
- Enzymatic Synthesis of Anandamide, an Endogenous Cannabinoid Receptor Ligand, through N-Acylphosphatidylethanolamine Pathway in Testis: Involvement of Ca2+-Dependent Transacylase and Phosphodiesterase ActivitiesBiochemical and Biophysical Research Communications, 1996
- Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brainBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1995
- Formation and inactivation of endogenous cannabinoid anandamide in central neuronsNature, 1994
- The Basal Ganglia and Adaptive Motor ControlScience, 1994
- Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid ReceptorScience, 1992
- The Neostriatal Mosaic: Multiple Levels of Compartmental Organization in the Basal GangliaAnnual Review of Neuroscience, 1992
- Structure of a cannabinoid receptor and functional expression of the cloned cDNANature, 1990