Effect of Early Postnatal Starvation on Subsequent Thyroid Function

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Abstract
Four male rats from each of 48 litters were studied. Two from each litter suffered early postnatal starvation; two did not. All animals were injected with 2 μCi of 131I. 24 h after injection, the thyroids were removed and weighed and their activity counted. In 27 litters, the age at time of injection was 30–35 days. In the other 21 it was 55 days. The in vitro uptake of triiodothyronine by the serum proteins, and the protein-bound iodine were determined at 45 days of age in the 21 litters noted above. The starved animals had higher uptake of T3, lower PBI, more thyroid tissue per unit of body size, less hormone production (estimated) per unit of thyroid tissue, and less hormone per unit of body mass. An economical method of measuring the in vitro uptake of T3 by the serum proteins is presented.

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