The semi-synthetic thienamycin derivative MK0787 and its properties with respect to a range of β-lactamases from clinically relevant bacterial species
- 28 February 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 7 (3) , 279-285
- https://doi.org/10.1093/jac/7.3.279
Abstract
The stability of the thienamycin derivative MK0787 has been evaluated in the presence of β-lactamases from Staphylococcus aureus and Bacteroides fragilis, as well as the Types Ia, IIIa and IVc enzymes. In all cases the antibiotic was very stable. MK0787 also proved to be a potent suicide inhibitor of the Type Ia and Bacteroides fragilis enzymes. With pure Type IIIa β-lactamase the Km and Vmax values for MK0787 were found to be 67.μM and about 0 1 μmol antibiotic destroyed/μg/pure enzyme/min respectively.Keywords
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