Mechanisms of MHC class I‐restricted antigen processing and cross‐presentation
Top Cited Papers
- 23 September 2005
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 207 (1) , 145-157
- https://doi.org/10.1111/j.0105-2896.2005.00316.x
Abstract
In this review, we discuss recent data from our laboratory that address two aspects of major histocompatibility complex (MHC) class I-restricted antigen processing. First, we consider the nature of the peptide-loading complex, which is the assembly of proteins in the endoplasmic reticulum (ER) into which newly synthesized MHC class I-beta(2) microglobulin (beta(2)m) heterodimers are incorporated, and the mechanisms involved in MHC class I assembly and peptide loading that are facilitated by the peptide-loading complex. Second, we discuss mechanisms of cross-presentation, the phenomenon whereby extracellular and luminal protein antigens can be processed by antigen-presenting cells, particularly dendritic cells, and presented by MHC class I molecules to CD8(+) T cells. The focus of the discussion is mainly on the human MHC class I system.Keywords
This publication has 63 references indexed in Scilit:
- Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cellsInternational Immunology, 2004
- Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?Trends in Cell Biology, 2004
- A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expressionEuropean Journal of Immunology, 2003
- Identification of Specific Glycoforms of Major Histocompatibility Complex Class I Heavy Chains Suggests That Class I Peptide Loading Is an Adaptation of the Quality Control Pathway Involving Calreticulin and ERp57Journal of Biological Chemistry, 2002
- Human Cytomegalovirus Gene Products US2 and US11 Differ in Their Ability To Attack Major Histocompatibility Class I Heavy Chains in Dendritic CellsJournal of Virology, 2002
- Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosisThe EMBO Journal, 2001
- Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2European Journal of Immunology, 1997
- CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULESAnnual Review of Immunology, 1997
- Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAPImmunity, 1996
- Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAPCurrent Biology, 1996