The Antibacterial Action of Tetrachlorsalicylanilide
- 1 September 1966
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 44 (3) , 343-352
- https://doi.org/10.1099/00221287-44-3-343
Abstract
Tetrachlorsalicylanilide (TCS) is a skin germicide which is bacteriostatic for Gram-positive bacteria at low concentrations and bactericidal at high concentrations; both activities are dependent on inoculum size and are not specific to a particular growth phase. Glucose oxidation by Staphylococcus aureus was inhibited at TCS 1 [mu]g/ml whereas 20 Jig/ml was required to inhibit glucose fermentation. S aureus treated with TCS which released amino acids did not accumulate C14 -labelled 1-glutamic acid, 1-lysine, 1-aspartic acid or sodium succinate. Inhibition by TCS of these processes as well as bacteriostasis was annulled by subsequent treatment with normal horse serum.This publication has 16 references indexed in Scilit:
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