SEQUENTIAL HISTOPATHOLOGY OF CAVITARY LIVER-ABSCESS - FORMATION INDUCED BY AXENICALLY GROWN ENTAMOEBA-HISTOLYTICA

  • 1 January 1980
    • journal article
    • research article
    • Vol. 104  (11) , 575-579
Abstract
Multiple hamster liver passage of E. histolytica trophozoites with intervening recovery into axenic culture caused increased virulence as measured by increase in the size of the lesion produced. Lesions produced by amoebae that were liver-passaged did not persist; however, multiply liver-passaged substrains produced large, fluid-filled abscesses 1 mo. to 6 wk after inoculation. Six days after inoculation, lesions consisted of multiple granulomas, lymphocytes and E. histolytica trophozoites. Large, fluid-filled abscesses produced by liver-passaged substrains lacked the granulomatous appearance of the earlier lesions. The abscesses had a fibrous wall, with E. histolytica trophozoites at the inner aspect. The evolution of early granulomatous lesions into a cavitary abscess with features closely resembling those of human amoebic abscess was not reported previously in the experimental disease in the hamster.

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