Locally produced C5a binds to T cell–expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis
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Open Access
- 1 September 2008
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 112 (5) , 1759-1766
- https://doi.org/10.1182/blood-2008-04-151068
Abstract
Our recent studies have shown that immune cell–produced complement provides costimulatory and survival signals to naive CD4+ T cells. Whether these sThis publication has 30 references indexed in Scilit:
- Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T CellsImmunity, 2008
- Life and death in peripheral T cellsNature Reviews Immunology, 2007
- Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of AutoimmunityImmunity, 2007
- In vivo regulation of neutrophil apoptosis by C5a during sepsisJournal of Leukocyte Biology, 2006
- Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cellsNature Immunology, 2003
- THE ALLOGENEIC T AND B CELL RESPONSE IS STRONGLY DEPENDENT ON COMPLEMENT COMPONENTS C3 AND C41Transplantation, 2001
- In Situ Localization of C3 Synthesis in Experimental Acute Renal Allograft RejectionThe American Journal of Pathology, 2000
- Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in VivoThe Journal of Experimental Medicine, 2000
- Fas(CD95)/FasL interactions required for programmed cell death after T-cell activationNature, 1995
- Relationship between decay accelerating factor deficiency, diminished acetylcholinesterase activity, and defective terminal complement pathway restriction in paroxysmal nocturnal hemoglobinuria erythrocytes.Journal of Clinical Investigation, 1987