The First General Method for Stille Cross-Couplings of Aryl Chlorides

Abstract
A “one-two punch” comprising two commercially available reagents, PtBu3 and CsF, provides a practical and general solution for a long-standing limitation of the Stille reaction—the inability to couple inexpensive and readily available aryl chlorides [Eq. (1); R1=OMe, NH2, o-Me, etc.; R=vinyl, allyl, Ph, Bu, etc.].

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