Differential Analysis of Cyclocytidine, 1-β-D-Arabinofuranosylcytosine, and 1-β-D-Arabinofuranosyluracil by Ultraviolet Spectophotometry2

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Abstract
A method has been devised for the measurement of cyclocytidine, 1-β-D-arabinofuranosylcytosine, and 1-β-D-arabinofuranosyluracil in the serum or plasma of dogs, monkeys, and man. The method depends on the resolution of a single ultraviolet curve into 3 component parts by the solution of 3 simultaneous linear equations. Significant advantages of the method are that it avoids the necessity of preliminary separation of the components by other means and that it does not depend on the use of radioactive material. The method has been used successfully in monkeys and dogs to monitor the disappearance of cyclocytidine.

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