THE RELEASE OF CORTICOTROPHIN DURING SEVERE STRESS IN THE RAT TREATED WITH PENTOBARBITONE AND MORPHINE

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Abstract
Suppression of corticotropin release by pentobarbitone and morphine was attempted in rats in whom adrenal vein blood was being collected. Corticotropin release, as indicated by a fall in the adrenal ascorbic acid, was neither inhibited or appreciably delayed under known circumstances which in the absence of morphine ordinarily produce adrenocortical secretion of maximum intensity. Doses of pentobarbitone sodium which rapidly lead to full anesthesia do not cause a release of corticotropin while slightly smaller doses release corticotropin in the absence of any further stimulus.