Neonatal Pancreatic β-Cell Hyperplasia: Report of a Case With Failure of Diazoxide and Benefit of Early Subtotal Pancreatectomy

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Abstract
A newborn infant with pancreatic β-cell hyperplasia had persistent hypoglycemia due to hyperinsulinism. After medical management, including the use of diazoxide and constant glucose infusions had proved ineffective, a subtotal pancreatectomy was curative. Cumulative experience seems to indicate that there should be little delay in performing a subtotal pancreatectomy when aggressive medical management cannot maintain normoglycemia in a neonate.

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