RADIATION INJURY AND MARROW REPLACEMENT: FACTORS AFFECTING SURVIVAL OF THE HOST AND THE HOMOGRAFT

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Abstract
The problems of marrow transplantation in mice, dogs, and men after lethal total-body irradiation are briefly reviewed in the light of recent experience. Large doses of radiation, 800 to 1000 r, are required in animals as preparation for the successful homograft of marrow or for useful effect on leukemia. Administration of similar large doses to man, with the finesse and uniformity necessary for safety, is not possible with usual radiologic equipment Procurement and preparation of human marrow are relatively simple. Intravenous injection with proper precaution appears to be harmless. The shortcomings of marrow as a material for restoring lymphoid defenses after irradiation are outlined. A potential remedy, in the form of injections of fetal lymphoid tissue, is suggested. This problem, the restoration of lymphoid defenses and the management of infection in the irradiated subject, is difficult and requires further exploration. It and the problem of appropriate radiologic facilities deserve immediate attention.