EFFECTS OF 12-0-TETRADECANOYLPHORBOL-13-ACETATE AND MEZEREIN ON EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY, ISOPROTERENOL-STIMULATED LEVELS OF CYCLIC ADENOSINE 3'-5'-MONOPHOSPHATE, AND INTRODUCTION OF MOUSE SKIN TUMORS INVIVO

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (12) , 4791-4795
Abstract
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the antileukemic agent mezerein are diterpene esters of plant origin with certain structural similarities. Both compounds, when applied topically to mouse skin, were equipotent on a molar basis in inducing hyperplasia, inflammation and ornithine decarboxylase activity, as well as in reducing cyclic AMP accumulation in response to .beta.-adrenergic stimulation. Mezerein was much less effective as a tumor promoter; the phorbol ester at 8.5 nmol/application yielded 78-fold more tumors than did 8.5 nmol mezerein per application to similarly initiated SENCAR mice. The superiority of the phorbol ester was nearly as great in CD-1 mice. Although the induction of hyperplasia and ornithine decarboxylase activity may be necessary components of the carcinogenic process, they are not sufficient; 12-O-tetradecanoylphorbol-13-acetate must accomplish an essential event not accomplished by mezerein.

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