Effect of Feeding and Fasting on Excretion of Phenobarbital in the Rabbit
- 1 January 1968
- journal article
- research article
- Published by Taylor & Francis in Clinical Toxicology
- Vol. 1 (3) , 297-307
- https://doi.org/10.3109/15563656808990583
Abstract
The present investigation was prompted by our observation of what appeared to be a circadian rhythm in the excretion of phenobarbital in rabbits 111. The effect was seen when the amount of phenobarbital excreted during each 6-hr period of urine collection was expressed as percent phenobarbital C14 per total C14 radioactivity in each sample, Since these initial observations were limited to 3 rabbits, the present investigation was undertaken to further establish the occurrence of the phenomenon. Further more, a mechanism is described through which the circadian rhythm in excretion is controlled in the rabbit.Keywords
This publication has 3 references indexed in Scilit:
- Control of Urine pH and Its Effect on Sulfaethidole Excretion in HumansJournal of Pharmaceutical Sciences, 1962
- Relationship between food and water ingestion in the rabbitAmerican Journal of Physiology-Legacy Content, 1961
- The Distribution and Excretion of Phenobarbital1Journal of Clinical Investigation, 1957