Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.
- 1 May 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (9) , 2864-2867
- https://doi.org/10.1073/pnas.81.9.2864
Abstract
Anti-idiotypic antibodies are described that were raised against murine monoclonal antibody 8.2, an antibody specific for a human melanoma-associated cell surface marker called p97. The 8.2 idiotopes recognized by this anti-idiotypic antiserum are binding site-associated and are shared by other monoclonal anti-p97 antibodies with the same specificity as antibody 8.2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma (p97-positive) tumor cells.Keywords
This publication has 34 references indexed in Scilit:
- Suppressor mechanisms in tumor immunityCellular and Molecular Life Sciences, 1983
- Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.The Journal of Experimental Medicine, 1982
- Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype AntibodyNew England Journal of Medicine, 1982
- Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine productionClinical Immunology and Immunopathology, 1981
- Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen.The Journal of Experimental Medicine, 1981
- Induction of idiotype-bearing, nuclease-specific helper T cells by in vivo treatment with anti-idiotype.The Journal of Experimental Medicine, 1981
- Genetic control of the immune response to staphylococcal nuclease XI. Effects of in vivo administration of anti‐idiotypic antibodiesEuropean Journal of Immunology, 1981
- Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies.The Journal of Experimental Medicine, 1980
- Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti-idiotypic antibodies in rabbits.The Journal of Experimental Medicine, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970