Synthesis and preliminary biological evaluation of 5-fluoro-5,8-dideazaisoaminopterin
- 1 November 1990
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 27 (7) , 2081-2084
- https://doi.org/10.1002/jhet.5570270742
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- Direct synthesis of 2,4‐diaminoquinazolines from 2‐fluorobenzonitrilesJournal of Heterocyclic Chemistry, 1988
- Trimetrexate for the Treatment ofPneumocystis cariniiPneumonia in Patients with the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1987
- Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infectionAntimicrobial Agents and Chemotherapy, 1987
- Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.The Journal of Experimental Medicine, 1987
- Biochemical pharmacology of the lipophilic antifolate, trimetrexateAdvances in Enzyme Regulation, 1984
- Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogsJournal of Medicinal Chemistry, 1984
- Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediaminesJournal of Medicinal Chemistry, 1983
- Potential antileprotic agents. 3. Inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolinesJournal of Medicinal Chemistry, 1974
- Antimalarial drugs. 24. Folate antagonists. 2. 2,4-Diamino-6-{[aralkyl and (heterocyclic)methyl]amino}quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' diseaseJournal of Medicinal Chemistry, 1972
- DISCUSSION PAPER: NEW APPROACHES TO CHEMOTHERAPYAnnals of the New York Academy of Sciences, 1971