CLONAL T-CELL POPULATIONS IN PITYRIASIS LICHENOIDES ET VARIOLIFORMIS ACUTA (MUCHA-HABERMANN DISEASE)

  • 1 March 1987
    • journal article
    • research article
    • Vol. 126  (3) , 417-421
Abstract
Patients with the skin disorder pityriasis lichenoides et varioliformis acuta (PLEVA) develop recurrent, self-healing papulonecrotic lesions that contain infiltrates of cytologically and antigenically normal T lymphocytes. DNA extracted from the lesions of 3 patients with PLEVA was analyzed for rearrangement of .beta.-T-cell receptor genes fro the purpose of assessing the clonality of T lymphocytes within the tissues of this disease. Lesions from all 3 cases showed clonal gene rearrangements. In each of 2 cases from which two separate lesions were biopsied, identical rearrangements were found in specimens from both sites. DNA from a variety of inflammatory lesions obtained from patients with other types of skin diseases failed to show detectable rearrangements of .beta.-T-cell receptor genes. These results suggest that PLEVA represents a T-cell lymphoproliferative process, rather than an inflammatory disorder, as had been previously thought.