Coexistence of familial antiphospholipid syndrome and factor V Leiden: impact on thrombotic diathesis

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Abstract
Two young siblings who presented with an unusual recurrent severe thromboembolic phenomenon were found to have familial anti-phospholipid syndrome and were heterozygous for the factor V R506Q mutation. The coexistence of hereditary and acquired APC-resistance may explain the severity of thromboembolism.

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