Simultaneous occurrence of t(14;18) and t(8;22) common acute lymphoblastic leukemia

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Abstract
A young male patient progressed rapidly from localized abdominal lymph node enlargement to overt acute lymphoblastic leukemia. Despite aggressive treatment, he died of progressive CNS leukemia 5 months after initial presentation. At diagnosis, karyotypic analysis of an abdominal lymph node revealed the coexistence of t (14; 18) (q32; q21), specific for follicular lymphoma, and t (8; 22) (q24; q11), a variant Burkitt translocation. Such cases might be considered as a model for a general mechanism of tumor progression with cascade-like involvement of oncogenes.