Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?
- 28 May 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 58 (10) , 1566-1568
- https://doi.org/10.1212/wnl.58.10.1566
Abstract
Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Aβ load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B(-511) on Aβ40 load (p < 0.05) was detected.Keywords
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