RESPIRATORY RESPONSE IN SENSITIZED RATS TO AEROSOL CHALLENGE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 34  (3) , 465-470
Abstract
Hooded Lister rats were sensitized to DNP[dinitrophenylated]-ovalbumin. These rats showed a significant alteration in respiratory pattern when challenged with DNP-ovalbumin aerosol. The respiratory response was not produced by challenging sensitized rats with intragastric DNP-ovalbumin. The magnitude of the respiratory response did not correlate with the specific Ig[immunoglobulin]E concentration in the serum. A similar pattern of respiratory response was inducible in unsensitized rats by i.v. administration of IgE-rich sera.