Laminar analysis of 2-deoxyglucose uptake in olfactory bulb and olfactory cortex of rabbit and rat

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Abstract
A method for mapping active regions of the olfactory bulb, based on the use of radioactively labeled 2-deoxyglucose (Sokoloff method) to localize sites of glucose uptake by active cells, was applied to a laminar analysis of the olfactory bulb and olfactory cortex in rabbits and rats. In the olfactory bulb of resting animals the main histological laminae were correlated with distinct levels of activity. Small dense foci were present in the autoradiographs, localized precisely over the glomerular layer. In rats exposed to the odor of amyl acetate broader regions of increased density were present bilaterally in the glomerular layer of the medial and lateral aspects of the bulb. The results provided evidence for spatial patterns of activity related to olfactory processing in the bulb. Density patterns were also present in olfactory cortex, correlated with the histological laminae.

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