In vivo release of [3H]-purines by quinolinic acid and related compounds
Open Access
- 1 October 1983
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 80 (2) , 263-267
- https://doi.org/10.1111/j.1476-5381.1983.tb10029.x
Abstract
1 In vivo release of [3H]-purines from the cortex of anaesthetized rats was measured and the actions of excitatory amino acids and analogues investigated. 2 High KCl, N-methyl-dl-aspartate (NMDLA) and quinolinic acid produced a large increase in basal release of labelled materials. Glutamate, quisqualate and kainate had less effect. 3 The N-methyl-d-aspartic acid (NMDA)-preferring receptor antagonist, 2-amino-7-phosphono-heptanoic acid, significantly reduced the release evoked by NMDLA and quinolinate but not that produced by the other agonists. 4 Kynurenic acid, a compound metabolically related to quinolinic acid, reduced the release due to NMDLA and quinolinate but not glutamate. 5 The results add further support to the suggestion that quinolinic acid acts on the NMDA-preferring receptor.This publication has 18 references indexed in Scilit:
- Post-excitatory depression of neuronal firing by acidic amino acids and acetylcholine in the cat spinal cordBrain Research, 1983
- Quinolinic acid: regional variations in neuronal sensitivityBrain Research, 1983
- Convulsant action of intracerebroventricularly administered l-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationshipsNeuropharmacology, 1982
- Excitatory effects of kynurenine and its metabolites, amino acids and convulsants administered into brain ventricles: Differences between rats and miceJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1982
- Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitantsNeuroscience Letters, 1982
- An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acidBrain Research, 1982
- Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNSEuropean Journal of Pharmacology, 1981
- Factors affecting the release of purines from mouse cerebral cortex: Potassium removal and metabolic inhibitorsBiochemical Pharmacology, 1981
- Kynurenines and SeizuresEpilepsia, 1981
- Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neuronesNeuroscience Letters, 1981