MIGRATION OF YOLK-SAC CELLS TO THYMUS GRAFTS - REQUIREMENT OF PRIOR SOJOURN IN BONE-MARROW (OR LIVER)

  • 1 January 1976
    • journal article
    • research article
    • Vol. C127  (6) , 943-949
Abstract
The migration of [mouse] CBA/HT6T6 hemopoietic cells (adult bone marrow, embryonic liver or yolk sac) to established thymus grafts, in CBA/H 60-day neonatally thymectomized hosts, shows that all 3 cell types can migrate and divide within the grafts, albeit yolk sac cells appear later after cell injection. There may be possible intermediate steps, i.e., a sojourn in bone marrow (or liver in the embryos). When the same experiments were performed in hosts that were pre-treated with 100 .mu.Ci of 89Sr (a bone seeking isotope), marrow and embryonic liver cells still could migrate to thymus and subsequently generate a population of competent T [thymus-derived] lymphocytes, while yolk sac cells were incapable of such migration.

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