Kumada–Corriu reactions in a pressure-driven microflow reactor
- 21 August 2001
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 1 (2) , 164-166
- https://doi.org/10.1039/b104035a
Abstract
Reaction rates for the Kumada reaction (of Grignard reagents with aryl halides) catalysed by an immobilised nickel(II) catalyst have been shown to be enhanced when the reaction is carried out in a pressure driven microreactor (internal diameter 100–200 µm) rather than with conventional batch reaction techniques.Keywords
This publication has 6 references indexed in Scilit:
- The application of micro reactors to synthetic chemistryChemical Communications, 2001
- Palladium-Catalyzed Cross-Coupling Reactions of Organoboron CompoundsChemical Reviews, 1995
- Palladium catalyzed synthesis of aryl, heterocyclic and vinylic acetylene derivativesJournal of Organometallic Chemistry, 1975
- The reaction of σ-vinylpalladium complexes with alkyllithiums. Stereospecific syntheses of olefins from vinyl halides and alkyllithiumsJournal of Organometallic Chemistry, 1975
- Selective carbon-carbon bond formation by cross-coupling of Grignard reagents with organic halides. Catalysis by nickel-phosphine complexesJournal of the American Chemical Society, 1972
- Activation of Grignard reagents by transition-metal complexes. A new and simple synthesis of trans-stilbenes and polyphenylsJournal of the Chemical Society, Chemical Communications, 1972