CELL-CYCLE AND MORPHOLOGICAL-CHANGES DURING GROWTH AND DIFFERENTIATION OF A RAT BASOPHILIC LEUKEMIA CELL LINE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (9) , 3131-3137
Abstract
Cells of the rat basophilic leukemia cell line RBL-1 differentiate maximally when permitted to achieve growth arrest in a high density stationary phase, in which the cell number is constant, and the cells are arrested in the G1 phase of the cycle. Features of differentiation are the accumulation of large basophilic granules and increases in membrane receptors for immunoglobulin E. Changes in histamine content did not parallel granule development or changes in immunoglobulin receptor concentration. During rapid forced exponential growth, the cell number doubles every 8 h, 50% of the cells are in S phase and differentiation is minimal.

This publication has 2 references indexed in Scilit: